Academic education:
Sep 1998-Jul 2003, Peking University Health Science Center, Bachelor Degree
Sep 2003-Jul 2007, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Master Degree
Sep 2009-Dec 2012, Eye Institute of Xiamen University, Ph.D.

Research Experience:
Oct 2006-July 2009, Eye Institute of Xiamen University, Assistant Research Specialist
Aug 2009-March 2013, Eye Institute of Xiamen University, Research Specialist
Apr 2013-so far, Eye Institute of Xiamen University, Assistant Professor

Research interests:

1. Dry Eye; 2. Ocular surface immunity

SCI papers published in the last 3 years:

1. Jiaoyue Hu#, Ning Gao, Yun Zhang, Xin Chen, Jinmiao Li, FangBian, Wei Chi, Zuguo Liu, Cintia de Paiva, Stephen C. Pflugfelder and De-Quan Li*. IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation, Mucosal Immunology, 2020 Nov;13(6):919-930.

2. Weijie Ouyang#, Shoubi Wang#, Jiaoyue Hu* (Co-Correspanding) and Zuguo Liu*. Can the cGAS-STING Pathway Play a Role in the Dry Eye? Frontiers in Immunology. 2022 Jun 24;13:929230.

3. Weijie Ouyang#, Yang Wu, Xiang Lin, Shoubi Wang, Yiran Yang, Liying Tang, Zhaolin Liu, Jieli Wu, Caihong Huang, Yueping Zhou, Xiaobo Zhang, Jiaoyue Hu* (Co-Correspanding) and 4. Zuguo Liu*. Role of CD4+ T helper cells in the development of BAC-induced dry eye syndrome in mice, Invest Ophthalmol Vis Sci. 2021 Jan 4;62(1):25.

5. Xiang Lin#, Yang Wu, Liying Tang, Weijie Ouyang, Yiran Yang, Zhaolin Liu, Jieli Wu, Xiaoxiang Zheng, Caihong Huang, Yueping Zhou, Xiaobo Zhang, Yongxiong Chen, Wei Li, Jiaoyue Hu* (Correspanding) and Zuguo Liu. Comparison of Treatment Effect and Tolerance of the Topical Application of Mizoribine and Cyclosporine A in a Mouse Dry Eye Model, Transl Vis Sci Technol., 2020 Dec 15;9(13):22.

6. Ruzhi Deng#, Xin Chen, Yun Zhang, Fang Bian, Ning Gao, Jiaoyue Hu, Changjun Wang, Rodrigo G. de Souza, Fan Lu, Stephen C. Pflugfelder and De-Quan Li*. Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation, Mucosal Immunology, 2019 Sep;12(5):1141-1149.

7. De-Quan Li#*; Sangbae Kim; Jinmiao Li; Qianmiao Gao; Jongsu Choi; Fang Bian; Jiaoyue Hu; Yun Zhang; Jin Li; Rong Lu; Yumei Li; Stephen C. Pflugfelder; Hongyu Miao; Rui Chen*. Single-Cell Transcriptomics Identifies Limbal Stem Cells Population and Cell Types Mapping Its Differentiation Trajectory in Limbal Basal Epithelium of Human Cornea, the Ocular Surface, 2021 Apr;20:20-32.

8. Sanming Li#, Liying Tang#, Jing Zhou, Sonia Anchouche, Dian Li, Yiran Yang, Zhaolin Liu, Jieli Wu, Jiaoyue Hu, Yueping Zhou, Jia Yin, Zuguo Liu*, Wei Li*. Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film. Stem Cell Reports. 2022 May 10;17(5):1105-1119.

9. Cheng X#, He D, Liao C, Lin S, Tang L, Wang YL, Hu J, Li W, Liu Z, Wu Y*, Liao Y*. IL-1/IL-1R signaling induced by all-trans-retinal contributes to complement alternative pathway activation in retinal pigment epithelium, J Cell Physiol. (Journal of Cellular Physiology), 2021 May;236(5):3660-3674.

10. Jin-Miao Li#, Sangbae Kim, Yun Zhang, Fang Bian, Jiaoyue Hu, Rong Lu, Stephen Pflugfelder, Rui Chen, and Dequan Li*. Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus, Invest Ophthalmol Vis Sci. 2021 Jul 1;62(9):36.

11. Shaopan Wang#, Xin He, Qingmin Li, Yuhan Zhang, Jiaoyue Hu, Rongrong Zong, Jingyi Zhuang, Andrew J Quantock, Yingying Gao*, Wei Li*, Zuguo Liu*. Obstructive sleep apnea affects lacrimal gland function, Invest Ophthalmol Vis Sci. 2022 Mar 2;63(3):3.

12. Liu Z#, Jin M, Li Y, Liu J, Xiao X, Bi H, Pan Z, Shi H, Xie X, Zhang M, Gao X, Li L, Ouyang W, Tang L, Wu J, Yang Y, Hu J, Liu Z*, Efficacy and Safety of Houttuynia Eye Drops Atomization Treatment for Meibomian Gland Dysfunction-Related Dry Eye Disease: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial. J Clin Med, 2020 Dec 12;9(12):E4022.

Grants：

1. National Natural Science Foundation of China (Beijing, China), Grants U20A20363

2. National Natural Science Foundation of China (Beijing, China), Grants 81100638

3. Lions Foundation for Sight (LFFS) (Houston, USA)

4. Natural Science Foundation of Fujian Province (Fujian, China), Grants 2015J0135

5. the Fundamental Research Funds for the Central Universities(Beijing, China) , 20720200023