Yalin Wu-Ophthalmic Institute of Xiamen University

Faculty

Yalin Wu

Title: Professor

Degree: Ph.D.

Department: Ophthalmology and Visual Science

Research field: Pathogenesis and drug discovery of dry age-related macular degeneration and autosomal recessive Stargardt‘s disease

Email: yalinw@xmu.edu.cn

Tel: +86-(0)592-2183761

Profile:

Professor Yalin Wu received his B.S. degree in biochemical engineering from Nanjing University of Technology in 2002, and completed his Ph.D. from Zhejiang University in chemistry. When he graduated in the spring of 2007, he first began postdoctoral work in the lab of Prof. Koji Nakanishi at the Chemistry Department of Columbia University, and later moved to Janet R. Sparrow's lab as a postdoctoral research scientist at the Ophthalmology Department of Columbia University Medical Center. He returned to mainland China in 2011 when he became a special-term professor (Principal Investigator, Ph.D. Supervisor) at the Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University. In 2012, he also was invited to be an adjunct professor at the Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University. In September 2015, He joined Xiamen University School of Medicine as a full professor of ophthalmic sciences.

Selected Publications:
（link to PubMed for all publications）

1. Cai B, Liao C, He D, Chen J, Han J, Lu J, Qin K, Liang W, Wu X, Liu Z, and Wu Y*.Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina. J. Biol. Chem. 2022, 298(2), 101553.

2. Chen C, Chen J, Wang Y, Liu Z, and Wu Y*.Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance. J. Biol. Chem. 2021, 296, 100187.

3. Liao C, Cai B, Feng Y, Chen J, Wu YP, Zhuang J, Liu Z, and Wu Y*.Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice. J. Biol. Chem. 2020, 295(20), 6958-6971.

4. Liao Y#, Zhang H#, He D, Wang Y, Cai B, Chen J, Ma J, Liu Z, and Wu Y*.Retinal pigment epithelium cell death is associated with NLRP3 inflammasome activation by all-trans retinal. Invest. Ophthalmol. Vis. Sci. 2019, 60(8), 3034-3045.

5. Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J, Liu Z, and Wu Y*. Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina. J. Biol. Chem. 2018, 293(37), 14507-14519.

6. Zhao J, Liao Y, Chen J, Dong X, Gao Z, Zhang H, Wu X, Liu Z, and Wu Y*.Aberrant buildup of all-trans-retinal dimer, a non-pyridinium bisretinoid lipofuscin fluorophore, contributes to the degeneration of the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 2017, 58(2), 1063-1075.

7. Liu X, Chen J, Liu Z, Li J, Yao K*, and Wu Y*.Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids. Invest. Ophthalmol. Vis. Sci. 2016, 57(3), 1017-1030.

8. Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y*.Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration. Toxicol. Sci. 2015, 143(1), 196-208.

9. Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y*. Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin. Invest. Ophthalmol. Vis. Sci. 2014, 55(12), 8241-8250.

10. Wu Y*,Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X. Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'. Biochem. J. 2014, 460(3), 343-352.

11. Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*.Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells. J. Biol. Chem. 2013, 288(50), 35671-35682.

12. Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR*. Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid. J. Am. Chem. Soc. 2011, 133(4), 849-857.

13. Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR*. Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc. Natl. Acad. Sci. USA 2010, 107(16), 7275-7280.

14. Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR*. Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J. Biol. Chem. 2009, 284(30), 20155-20166.

Awards:

1. Chinese Ophthalmological Society Award (2018)

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