课题组成员:

副教授: 楚成超

研究生：蔡顺东、朱慧敏、叶锦法、程宇航、邱辰悦、郑龙怡

电话：0592-2183761

邮箱：chuchengchao@xmu.edu.cn

主要研究领域：

角膜新生血管诊疗一体化研究

角膜新生血管（CNV）是先天性疾病、炎症、化学烧伤、角膜缘干细胞缺乏、感染性角膜炎、自身免疫性疾病以及组织移植等一系列病理变化后，角膜边缘毛细血管中血管内皮细胞增殖并迁移到角膜基质行成的疾病，目前CNV成为了致盲的主要因素之一。本课题组致力于利用临床药物进行超分子组装进行药剂研发，通过对组装机制研究为眼药研发提供新方法；通过对新型眼药制剂对CNV重要靶标分子演进动态研究，为临床治疗提供指导。

近期代表论文：

1. Jingwen Yu, Yiming Wu, Qixuan Dai, Han Wu, Jintao Pan, Yuli Guo, Ke Yan, Huimin Zhu, Yi Mao, Sijie Lin, Wei Li *, Gang Liu*, Chengchao Chu*. In vivo assembly drug delivery strategy based on ultra-small nanoparticles: Toward high drug permeation and accumulation for CNV treatment. Chem. Eng. J., 2022, 450, 137968

2. Qixuan Dai, Lin Wang, En Ren, Hu Chen, Xing Gao, Hongwei Cheng, Yibo An, Chengchao Chu, Gang Liu. Ru-based Metal-Organic Nanoradiosensitizers Enhance Radiotherapy by Combining ROS Generation and CO Gas Release. Angew. Chem. Int. Ed., Doi: 10.1002/anie.202211674.

4. Huimin Zhu，Jingwen Yu，Jinfa Ye，Yiming Wu，Jintao Pan，Yingying Li，Chuan Chen，Li Zheng*, Gang Liu*, Chengchao Chu*. Nanoparticle-mediated corneal neovascularization treatments: Toward new generation of drug delivery systems. Chinese Chem. Letter., 2022 Doi: 10.1016/j.cclet.2022.06.071.

5. Jinqiang Liu, Shiying Fu, Jiaxuan Xie, Jianzhong Zhang, Jintao Pan, Chengchao Chu*, Gang Liu*, Shenghong Ju*. Application of Self-Assembly Nanoparticles Based on DVDMS for Fenton-Like Ion Delivery and Enhanced Sonodynamic Therapy. Biosensors 2022, 12, 255.

6. En Ren, Haimin Chen, Zainen Qin, Siwen Guan, Lai Jiang, Xin Pang, Yi He, Yang Zhang, Xing Gao, Chengchao Chu*, Li Zheng*, Gang Liu*. Harnessing Bifunctional Ferritin with Kartogenin Loading for Mesenchymal Stem Cell Capture and Enhancing Chondrogenesis in Cartilage Regeneration. Adv. Healthc. Mater., 2022, 2101715.

7. Yang Zhang, Hongwei Cheng, Hu Chen, Peiyao Xu, En Ren, Yonghe Jiang, Dengfeng Li, Xing Gao, Yating Zheng, Pan He, Huirong Lin, Biaoqi Chen, Gan Lin, Aizheng Chen, Chengchao Chu*, Jingsong Mao*, Gang Liu*. A pure nanoICG-based homogeneous lipiodol formulation: toward precise surgical navigation of primary liver cancer after long-term transcatheter arterial embolization. Eur. J. Nucl. Med. Mol. I., 2022, 49(8):2605-2617.

8. Dongsheng Li#, Qixuan Dai#, Hu Chen#, Huirong Lin, Zhixiang Lu, Huili Zheng, Peng Lv, Wei Li*, Gang Liu*, Chengchao Chu*. Metal-organic nanostructure based on TixOy/Ruthenium reaction Units: For CT/MR Imaging-Guided X-ray induced dynamic therapy. Chem. Eng. J., 2021, 417, 129262.

9. Zhixiang Lu, Shuang Bai, Yeshi Shi, Dazhuang Xu, Chengchao Chu*, Gang Liu*. Artificial nanocage-based 3D framework platforms: From construction design to biomedical applications. Chem. Eng. J., 2021, 426, 131891.

10. Dong Li, Yang Yang, Dengfeng Li, Jie Pan, Chengchao Chu*, Gang Liu*. Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development. Small, 2021, 202101976.

11. Chengchao Chu*#, Jingwen Yu#, En Ren#, Shangkun Ou, Yunming Zhang, Yiming Wu, Han Wu, Yang Zhang, Jing Zhu, Qixuan Dai, Xiaoyong Wang, Qingliang Zhao, Wei Li*, Zuguo Liu, Xiaoyuan Chen, Gang Liu*. Multimodal Photoacoustic Imaging-Guided Regression of Corneal Neovascularization: A Non-invasive and Safe Strategy. Adv. Sci., 2020, 202000346.

12. Huili Zheng#, Baoxin Ma#, Yesi Shi#, Qixuan Dai, Dongsheng Li, En Ren, Jing Zhu, Jianming Liu, Hu Chen, Zhenyu Yin, Chengchao Chu*, Xiaomin Wang*, Gang Liu*. Tumor Microenvironment-Triggered MoS2@GA-Fe Nanoreactor: A Self-Rolling Enhanced Chemodynamic Therapy and Hydrogen Sulfide Treatment for Hepatocellular Carcinoma. Chem. Eng. J., 2021, 406, 126888.

13. Xiaoxiao Shi#, Yang Zhang#, Ye Tian#, Shuyu Xu, En Ren, Shuang Bai, Xiaoyuan Chen, Chengchao Chu*, Zhigang Xu*, and Gang Liu*. Multi-responsive Bottlebrush-Like Unimolecules Self-Assembled Nano-Riceball for Synergistic Sono-Chemotherapy. Small Methods, 2021, 202000416.

14. Min Su#, Qixuan Dai#, Chuan Chen, Yun Zeng, Chengchao Chu*, Gang Liu*. Nano-Medicine for Thrombosis: A Precise Diagnosis and Treatment Strategy. Nano-Micro Letter., 2020, 12:96.

15. Hu Chen#, Hongwei Cheng,# Qixuan Dai,# Yi Cheng,# Yang Zhang, Dengfeng Li, Yang Sun, Jingsong Mao*, Ke Ren, Chengchao Chu*, Gang Liu*. A superstable homogeneous lipiodolICG formulation for locoregional hepatocellular carcinoma treatment. J. Control. Release, 2020, 323, 635-643.

16. Dazhuang Xu, Lei Li, Chengchao Chu*, Xiaoyong Zhang*, Gang Liu*. Advances and perspectives in near-infrared fluorescent organic probes for surgical oncology. WIREs Nanomed. Nanobi., 2020, 12(5):e1635.

17. Hu Chen#, Hongwei Cheng#, Wenying Wu#, Dengfeng Lia, Jingsong Mao*, Chengchao Chu*, Gang Liu*. The Blooming Intersection of Transcatheter Hepatic Artery Chemoembolization and Nanomedicine. Chinese Chem. Letter., 2020, 31, 1375-1381.

18. Chuan Chen, Rui Tian, Yun Zeng, Chengchao Chu*, Gang Liu*. Activatable fluorescence probes for “turn-on” and ratiometric biosensing and bioimaging: from NIR-I to NIR-II. Bioconjugate Chem., 2020, 31, 2, 276-292.