课题组成员：

副教授：陈倩

研究生：叶四豪、姜楠

电话：0592-2183761

邮箱：qchen2@xmu.edu.cn

研究方向：

糖尿病性视网膜病变

糖尿病性视网膜病变（简称糖网病）是糖尿病最常见的血管并发症之一。糖网病是西方国家致盲的首要原因，也是我国人口致盲的主要原因之一。糖网病的早期病理为毛细血管内皮细胞损伤、周细胞选择性丢失、血管基底膜增厚、微血管瘤的形成等。糖网病的晚期主要特征是视网膜新生血管的形成，渗出出血等。其中视网膜新生血管是糖网病患者致盲的最重要的病理变化。几乎所有1型糖尿病的患者在糖尿病的进程中会发生一定程度的糖网病，而50%-80%的2型糖尿病患者在病程20到25年左右会出现糖网病。随着糖尿病的增多，糖网病累及人口数会进一步的增加。目前糖网病的发病机制尚未完全明确且现有的治疗手段疗效欠佳。

本课题组运用多种糖尿病动物模型，分别研究Wnt/β-catenin信号通路、microRNAs、PPARα、VLDLR与糖尿病新生血管的关系，旨在理解糖网病的发病机理及找出有效的治疗手段。目前本课题组带头人已经在国内外知名杂志上Diabetes，MCB，IOVS等发表多篇SCI论文。

近期发表的论文：

1. Chen Q, Qiu FF, Zhou KL, Matlock G, Takahashi Y, Yang HF, Moran E, Ma JX. Pathological role of miR-21 in diabetic retinopathy through down-regulation of PPARα. DIABETES. 2017;66:1671–1682.

2. Chen Q, Ma JX. Canonical Wnt signaling in diabetic retinopathy. VISION RES. 2017;139:47-58.

3. Chen Q, Takahashi Y, Oka K, Ma JX. Functional differences of VLDLR splice variants in regulating Wnt signaling. Mol Cell Biol 2016;36:2645–2654.

4. Takahashi Y*, Chen Q*, Rajala R, Ma JX, MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS Lett, 2015;589(10):1143-9. (* equal contribution)

5. Murray AR*, Chen Q*, Takahashi Y, Zhou KK, Park K, Ma JX. MiRNA-200b down-regulates Oxidation Resistance 1 (Oxr1) expression in the retina of type 1 diabetes model. Invest Ophthalmol Vis Sci., 2013;54(3):1689-97. (* equal contribution)

6. Qiu FF, Matlock GH, Chen Q, Zhou KL, Du YH, Wang X and Ma JX. Therapeutic effects of PPARα agonist on experimental neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci., 2017 Oct 1;58(12):5065-5075.

7. Fu H, Vadalia N, Xue ER, Johnson C, Wang L, Yang WY, Sanchez C, Nelson J, Chen Q, Choi ET, Ma JX, Yu J, Wang H, Yang XF. Thrombus leukocytes exhibit more endothelial cell-specific angiogenic markers than peripheral blood leukocytes do in acute coronary syndrome patients, suggesting a possibility of trans-differentiation: a comprehensive database mining study. J Hematol Onco., 2017 Mar 23;10(1):74.

8. Moran E, Ding LX, Wang ZX, Cheng R, Chen Q, Moore R, Takahashi Y and Ma JX. Protective and Antioxidant Effects of PPAR-α in the Ischemic Retina. Invest Ophthalmol Vis Sci., 2014 May 13;55(7):4568-76.

9. Hu Y, Chen Y, Ding LX, He XM, Takahashi Y, Gao Y, Shen W, Cheng R, Chen Q, Qi XP, Boulton M, and Ma JX. Pathogenic role of diabetes-induced PPAR-α down-regulation in microvascular dysfunction. Proc. Natl. Acad. Sci., 2013.110 (38):15401-15406.