课题组成员：

助理教授：胡皎月

研究生：孟菊锋，叶立军，赵钟阳

电话：0592-2183761

邮箱：mydear_22000@163.com

研究方向：糖尿病性角膜病变

随着糖尿病患者的日益增加，其并发症引起了研究人员的广泛重视，糖尿病眼部并发症（包括糖尿病视网膜病变，糖尿病性白内障）是引起眼盲的重要原因之一。近年来，糖尿病性眼表病变引起了研究者的广泛重视，其表现包括：干眼症、角膜上皮损伤（包括上皮再生迟缓、浅层点状角膜炎、持续性上皮缺损、反复的上皮糜烂、浅层角膜溃疡、丝状角膜炎、大泡形成等）、角膜知觉下降等。氧化应激被认为是导致糖尿病性眼表病变的重要发病机制之一。本课题组致力于研究糖尿病性角膜病变的发病机制及治疗。
近期发表的文章：

1. Zhenhao Zhang, Yue Huang, Hui Xie, Juxin Pan, Fanfei Liu, Wensheng Chen, Jiaoyue Hu* (Co-Correspanding), Zuguo Liu*. Benzalkonium Chloride Suppresses Rabbit Corneal Endothelium Intercellular Gap Junction Communication, Plos One, 2014 Oct 9;9(10):e109708.

2. Wensheng Chen*, Nuo Dong, Caihong Huang, Zhenhao Zhang, Jiaoyue Hu, Hui Xie, Juxin Pan, Zuguo Liu*. Corneal Alternations Induced by Topical Application of Commercial Latantoprost, Travoprost and Bimatoprost in Rabbit, Plos One, 2014 Mar 14;9(3):e89205.

3. Wensheng Chen*, Zhenhao Zhang, Jiaoyue Hu, Hui Xie, Juxin Pan, Nuo Dong, Zuguo Liu*. Changes in Rabbit Corneal Innervation Induced by Topical Application of Benzalkonium Chloride, Cornea, 2013;Dec;32(12):1599-606.

4. Jiaoyue Hu#, Zhenhao Zhang#, Hui Xie, Lelei Chen, Yueping Zhou, Juxin Pan, Wensheng Chen*, Zuguo Liu*. Serine protease inhibitor A3K protects rabbit corneal endothelium from barrier function disruption induced by TNF-α, Invest Ophthalmol Vis Sci,2013;Aug 9;54(8):5400-7.

5. Wensheng Chen#, Jiaoyue Hu# (co-first author), Zhenhao Zhang, Lelei Chen, Hui Xie, Nuo Dong, Yongxiong Chen, Zuguo Liu. Localization and Expression of Zonula Occluens-1 in the Rabbit Corneal Epithelium Following Exposure to Benzalkonium Chloride.Plos One, 2012;7(7):e40893.