课题组成员:

教授：吴亚林

高级实验师：韩云

博士生：和丹雪、陶磊、杨博、郭舒婷、何倍婷

硕士生：杨坤欢、陈钰玲、谌小清

已离开课题组成员:

实验员：侯新惠、刘彦博

博士生：廖春燕、陈超、蔡彬祥

硕士生：高瞻

Tel: 86-592-2183761

E-mail: yalinw@xmu.edu.cn

研究方向：视网膜黄斑疾病

年龄相关性黄斑变性（AMD）是全球成人和我国中老年人群重度视力丧失甚至不可逆性盲的主要原因，俨然已经成为严重的公共卫生问题，极大地影响了我国中老年人的身体健康和生活质量，给国家和个人带来了沉重的思想及经济负担，严重地制约着我国的经济发展。AMD根据临床表现分为干性和湿性两型，干性AMD约占AMD患者总数的88%。常染色体隐性Stargardt病（STGD1）是一种遗传性黄斑营养不良，其使得数以万计的患儿步入成年期时遭受失明的痛苦。我们课题组主要研究干性AMD和STGD1的发生发展机制及其药物开发。

代表性论文:

1. Cai B, Liao C, He D, Chen J, Han J, Lu J, Qin K, Liang W, Wu X, Liu Z, and Wu Y*. Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina. J. Biol. Chem. 2022, 298(2), 101553.

2. Chen C, Chen J, Wang Y, Liu Z, and Wu Y*. Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance. J. Biol. Chem. 2021, 296, 100187.

3. Liao C, Cai B, Feng Y, Chen J, Wu YP, Zhuang J, Liu Z, and Wu Y*. Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice. J. Biol. Chem. 2020, 295(20), 6958-6971.

4. Liao Y^#, Zhang H^#, He D, Wang Y, Cai B, Chen J, Ma J, Liu Z, and Wu Y*. Retinal pigment epithelium cell death is associated with NLRP3 inflammasome activation by all-trans retinal. Invest. Ophthalmol. Vis. Sci. 2019, 60(8), 3034-3045.

5. Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J, Liu Z, and Wu Y*. Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina. J. Biol. Chem. 2018, 293(37), 14507-14519.

6. Zhao J, Liao Y, Chen J, Dong X, Gao Z, Zhang H, Wu X, Liu Z, and Wu Y*. Aberrant buildup of all-trans-retinal dimer, a non-pyridinium bisretinoid lipofuscin fluorophore, contributes to the degeneration of the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 2017, 58(2), 1063-1075.

7. Liu X, Chen J, Liu Z, Li J, Yao K*, and Wu Y*. Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids. Invest. Ophthalmol. Vis. Sci. 2016, 57(3), 1017-1030.

8. Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y*. Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration. Toxicol. Sci. 2015, 143(1), 196-208.

9. Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y*. Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin. Invest. Ophthalmol. Vis. Sci. 2014, 55(12), 8241-8250.

10. Wu Y*, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X. Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'. Biochem. J. 2014, 460(3), 343-352.

11. Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*. Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells. J. Biol. Chem. 2013, 288(50), 35671-35682.

12. Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR*. Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid. J. Am. Chem. Soc. 2011, 133(4), 849-857.

13. Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR*. Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc. Natl. Acad. Sci. USA 2010, 107(16), 7275-7280.

14. Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR*. Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J. Biol. Chem. 2009, 284(30), 20155-20166.