主要学术成果：

代表性论文：

1

Yang B, Yang K, Xi R, Chen Y, Han J, Li S,   Chen J, and Wu Y*. Activation of GSDME by all-trans-retinal   increases sensitivity to photoreceptor ferroptosis. Int.   J. Biol. Sci. 2025, 21(15), 7029-7042.

2

Shen X, Chen Y, He B, Xi R, Chen J, and Wu   Y*. Ferrostatin-1, a ferroptosis inhibitor, mitigates all-trans-retinal-induced   retinal pigment epithelium degeneration in mice. J. Transl. Med.   2025, 23(1), 1103.

3

Yang   B, Yang K, Xi R, Li S, Chen J, and Wu Y*. Long-term senolytic therapy   with Dasatinib and Quercetin alleviates lipofuscin-dependent retinal   degeneration in mice. Redox Biol. 2025, 85, 103716.

4

Yang B, Yang K, Chen Y, Li Q, Chen J, Li S*,   and Wu Y*. Exposure of A2E to blue light promotes ferroptosis in the   retinal pigment epithelium. Cell. Mol. Biol. Lett.   2025, 30(1), 22.

5

Tao L, He D, Chen Y, Yang K, He B, Cai P, Cai   B, Liao C, Liu Z, Li S, Chen J, and Wu   Y*. Transferrin ameliorates retinal degeneration by mediating the   dimerization of all-trans-retinal. J. Biol. Chem. 2025,   301 (1), 108054.

6

Yang   B, Yang K, Xi R, Li S, Chen J, and Wu Y*. Inhibition of JNK signaling   attenuates photoreceptor ferroptosis caused by all-trans-retinal. Free Radic. Biol. Med. 2025, 227, 179-189.

7

He D,   Tao L, Cai B, Chen X, Wang Y, Li S, Liao C, Chen Y, Chen J, Liu Z*, and Wu Y*. eIF2α incites photoreceptor cell and retina damage by all-trans-retinal. J. Biol. Chem. 2023, 299(5), 104686.

8

Chen   C, Yang K, He D, Yang B, Tao L, Chen J, and Wu Y*. Induction of ferroptosis by HO-1 contributes to retinal   degeneration in mice with defective clearance of all-trans-retinal. Free Radic. Biol. Med. 2023, 194,   245-254.

9

Cai B, Liao C, He D, Chen J, Han J, Lu J, Qin K,   Liang W, Wu X, Liu Z, and Wu Y*.   Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina. J. Biol. Chem. 2022,   298(2), 101553.

10

Chen C, Chen J, Wang Y, Liu Z, and Wu Y*. Ferroptosis   drives photoreceptor degeneration in mice with defects in all-trans-retinal   clearance. J. Biol. Chem. 2021, 296, 100187.

11

Liao C, Cai B, Feng Y, Chen J, Wu YP, Zhuang J, Liu   Z, and Wu Y*. Activation of JNK   signaling promotes all-trans-retinal-induced   photoreceptor apoptosis in mice. J. Biol. Chem. 2020, 295(20),   6958-6971.

12

Liao Y^#, Zhang H^#, He D, Wang   Y, Cai B, Chen J, Ma J, Liu Z, and Wu   Y*. Retinal pigment epithelium cell death is associated with NLRP3   inflammasome activation by all-trans   retinal. Invest. Ophthalmol. Vis. Sci. 2019, 60(8), 3034-3045.

13

Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J,   Liu Z, and Wu Y*. Conversion of   all-trans-retinal into all-trans-retinal dimer reflects an   alternative metabolic/antidotal pathway of all-trans-retinal in the retina. J. Biol. Chem. 2018, 293(37),   14507-14519.

14

Zhao J, Liao Y, Chen J, Dong X, Gao Z, Zhang H, Wu   X, Liu Z, and Wu Y*. Aberrant   buildup of all-trans-retinal dimer,   a non-pyridinium bisretinoid lipofuscin fluorophore, contributes to the   degeneration of the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci.   2017, 58(2), 1063-1075.

15

Liu X, Chen J, Liu Z, Li J, Yao K*, and Wu Y*. Potential therapeutic agents   against retinal diseases caused by aberrant metabolism of retinoids. Invest.   Ophthalmol. Vis. Sci. 2016, 57(3), 1017-1030.

16

Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y,   Naranmandura H, Liu X, and Wu Y*.   Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration. Toxicol.   Sci. 2015, 143(1), 196-208.

17

Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J,   and Wu Y*. Preparative and   biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores   of retinal pigment epithelial lipofuscin. Invest. Ophthalmol. Vis. Sci.   2014, 55(12), 8241-8250.

18

Wu Y*, Jin Q, Yao K, Zhao J,   Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X. Retinal metabolism in   humans induces the formation of an unprecedented lipofuscin fluorophore   'pdA2E'. Biochem. J. 2014, 460(3), 343-352.

19

Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*. Identification of a novel   lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment   epithelial cells. J. Biol. Chem. 2013, 288(50), 35671-35682.

20

Wu Y, Yanase E, Feng X, Siegel   M, and Sparrow JR*. Structural characterization of bisretinoid A2E   photocleavage products and implications for age-related macular degeneration.   Proc.   Natl. Acad. Sci. U. S. A. 2010, 107(16),   7275-7280.

承担国家级课题：

1

国家重点研发计划子课题，2024YFA1108701，2024.12-2027.11，主持

2

国家自然科学基金面上项目，82471093，2025.01-2028.12，主持

3

国家自然科学基金面上项目，82171064，2022.01-2025.12，主持

4

国家自然科学基金面上项目，81870671，2019.01-2022.12，主持

5

国家自然科学基金面上项目，81570857，2016.01-2019.12，主持

6

国家自然科学基金面上项目，81271018，2013.01-2016.12，主持

7

国家自然科学基金青年项目，21202146，2013.01-2015.12，主持

获奖：

1

厦门市科学技术进步奖（2024，第一完成人）

2

福建省自然科学奖（2023，第一完成人）

3

中华眼科学会奖（2018，个人奖励）