个人简历
邱彦 教授、博士生导师
学科方向:药理学/中药药理学
研究方向:代谢性疾病药物药理
单位:眼科研究所
办公室:医学院成智楼315
电子邮箱:yanqiu@xmu.edu.cn
研究领域
研究组采用来源于中药及海洋资源的天然产物、靶向合成药物等研究药物通过介导内源性脂类(如内源性大麻素、神经酰胺等)合成代谢及其在治疗代谢性疾病中的作用和机制
学习经历
2000-2005 沈阳药科大学中药学院 药物化学 博士
1996-2000 江西中医学院药学系 中药学 学士
工作经历
2016-至今 厦门大学医学院 教授;
2015-2016 意大利Sapienza University of Rome 访问学者;
2009-2016 厦门大学医学院 副教授;
2005-2009 厦门大学医学院 讲师;
社会兼职
1. 厦门市手性药物重点实验室,主任,2023年
2. 中国药理学会第十三届心血管药理专业委员会,委员,2021年
3. 中国药理学会海洋药物药理专业委员会,委员,2023年
4. 福建省药理学会第三届理事会,理事,2024年
5. 福建省药学会第七届药剂专业委员会,委员,2022年
6. 厦门市中医药学会药膳分会第一届委员会,副主任委员,2024年
研究项目
1. 国家自然科学基金面上项目,82274162,2023-01至2026-12,主持;
2. 国家重点研发计划项目,2022YFC2804103,2023-01至2025-12,骨干;
3. 国家自然科学基金面上项目,81373273,2014-01至2017-12,主持;
4. 国家自然科学基金项目,81273371,2013-01至2013-12,主持;
5. 国家自然科学基金青年项目,30600053,2007-01至2009-12,主持;
6. 新型冠状病毒防治应急科研攻关项目,20720200015,2020-02至2021-02,主持;
7. 国家卫生计生委共建科研基金——福建省卫生教育联合攻关计划项目,WKJ2016-2-03,2017-01至2019-12;主持;
8. 厦门南方海洋研究中心项目,14GYY018NF18,,2014-10至2016-12,主持;
9. 厦门市科技局项目,3502Z20113010,2011-01至2013-12,主持;
10. 福建省自然基金,2009J05088,2009-05至2011-12,主持
代表论文
1. Yuhang Li, Yitian Li, Sennan Xu, Yue Chen, Pan Zhou, Ting Hu, Hua Li, Ying Liu, Yaping Xu, Jie Ren, Yan Qiu*, Canzhong Lu*, N-Acylethanolamine acid amidase (NAAA) exacerbates psoriasis inflammation by enhancing dendritic cell (DCs) maturation, Pharmacological Research, 2022, 185, 106491, doi: 10.1016/j.phrs.2022.106491
2. Yun Han, Kunhuan Yang, Danxue He, Chaofeng Yu, Lei Tao, Chunyan Liao, Binxiang Cai, Zuguo Liu, Yan Qiu*, Yalin Wu*, Effect of palmitoylethanolamide on degeneration of a human-derived retinal pigment epithelial cell induced by all-trans retinal, International Journal of Ophthalmology, 2023, 16,191-200
3. Sennan Xu†, Lingjie Ke†, Sichen Zhao, Zhiguo Li, Yang Xiao, Yunlong Wu, Jie Ren*, Yan Qiu*, Thermosensitive Poly(DHSe/PEG/PPG Urethane)-Based Hydrogel Extended Remdesivir Application in Ophthalmic Medication, Pharmaceutics, 2022, 14, https://doi.org/10.3390/pharmaceutics14010050
4. Chunyan Ji†, Yuli Guo†, Ying Liu, Sennan Xu, Sichen Zhao, Xin Luo, Funan Qiu, Rui Huang, Qingyan Xu, Ruihe Zheng, Miao Xia, Yun Zhao, Jie Ren*, Yan Qiu*, Inhibition of ceramide de novo synthesis ameliorates meibomian gland dysfunction induced by SCD1 deficiency, Ocular Surface, 2021, 22: 230-241, doi: 10.1016/j.jtos.2021.08.016
5. Ruihe Zheng, Yibo Zhang, Funan Qiu, Zhaohui Liu, Yun Han, Rui Huang, Yun Zhao, Peijie Yao, Yan Qiu*, Jie Ren*, NF-κB pathway play a role in SCD1 deficiency-induced ceramide de novo synthesis, Cancer Biology & Therapy, 2021, 22(2): 164-174, doi: 10.1080/15384047.2021.1883414;
6. Yitian Li, Sichen Zhao, Sennan Xu, Yuhang Li, Chaowei Wang, Jie Ren, Fei Li, Xiaokun Hu, Kuantian Lin, Yan Qiu*, and Yanghui Xiu*, Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGFβ signaling through PPARα, Biochemical Pharmacology, 2020, 184:114398, doi.org/10.1016/j.bcp.2020.114398;
7. Longhe Yang, Chunyan Ji, Yitian Li, Fan Hu, Fang Zhang, Haiping Zhang, Long Li, Jie Ren, Zhaokai Wang*, Yan Qiu*, Natural potent NAAA inhibitor atractylodin counteracts LPS-induced microglial activation, Frontiers in Pharmacology, 2020, 11, 577319, doi: 10.3389/fphar.2020.577319;
8. Qi Chen, Chunyan Ji, Ruihe Zheng, Longhe Yang, Jie Ren, Yitian Li, Yun Han, Pan Zhou, Zuguo Liu*, Yan Qiu*, N-Palmitoylethanolamine maintains local lipid homeostasis to relieve sleep deprivation-induced dry eye syndrome, Frontiers in Pharmacology, 2020, 10, 1622, doi: 10.3389/fphar.2019.01622;
9. MinghuiWang, Longhe Yang, Liubin Feng, Fan Hu, Fang Zhang, Jie Ren, Yan Qiu*, Zhaokai Wang*, Verruculosins A–B, new oligophenalenone dimers from the soft coral-derived fungus talaromyces verruculosus, Marine Drugs, 2019, 17, 516;
10. Pan Zhou, Lei Xiang, Yulong Yang, Yuezhou Wu, Ting Hu, Xiaolong Liu, Feitai Lin, Yanghui Xiu, Kangni Wu, Canzhong Lu, Jie Ren, Yan Qiu*, Yuhang Li*, N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritis, Pharmacological Research, 2019, 145, 104264; https://doi.org/10.1016/j.phrs.2019.104264;
11. Yuhang Li, Pan Zhou, Huixia Chen, Qi Chen, Xiaofei Kuang, Canzhong Lu*, Jie Ren, and Yan Qiu*, Inflammation-restricted anti-inflammatory activities of a N-acylethanolamine acid amidase (NAAA) inhibitor F215, Pharmacological Research, 2018, 132, 7-14;
其他成果
1. 取代杂环衍生物、其制备方法和用途,ZL 201580059466.4;
2. Substituted heterocyclic derivative, preparation method and use thereof, US 10,174,015;
3. 一类取代杂环衍生物及其制备方法,ZL 201410603721.1
4. 一类取代杂环衍生物在制备治疗疼痛药物中的应用,ZL 201410604001.7;
5. 利用小分子化合物诱导干细胞向心肌分化的方法,ZL 201410629278.5;
6. 取代杂环衍生物、其制备方法和用途,WO2016/066115A1