所在位置: 首页 科学研究 课题组 正文
课题组
吴亚林教授课题组
访问量: 发布时间:2018年07月28日

 

课题组成员:

教授: 吴亚林

助理教授: 廖怿

高级实验师:韩云

实验员: 刘彦博

博士生: 廖春燕、陈超、蔡彬祥

硕士生:高瞻、和丹雪、陶磊、程心璇

已离开课题组成员:

实验员:侯新惠

本科生:张厚检、祝玉

Tel: 86-592-2183761

E-mail: yalinw@xmu.edu.cn




研究方向:

年龄相关性黄斑变性和斯特格(Stargardt)病的发病机制及其药物开发

年龄相关性黄斑变性(AMD)是全球成人和我国中老年人群重度视力丧失甚至不可逆性盲的主要原因,俨然已经成为严重的公共卫生问题,极大地影响了我国中老年人的身体健康和生活质量,给国家和个人带来了沉重的思想及经济负担,严重地制约着我国的经济发展。斯特格(Stargardt)病(STGD)也称为少年性黄斑变性,是一种原发于视网膜色素上皮层的常染色体隐性遗传眼底病,同样也使得数以万计的患者遭受失明的痛苦。我们主要研究视觉循环紊乱和脂褐素积聚在AMD、STGD发生发展中的作用机制以及相应地靶向药物防治。


代表性论文:

1. Gao Z, Liao Y, Chen C, Liao C, He D, Chen J, Ma J, Liu Z, and Wu Y*. Conversion of all-trans-retinal into all-trans-retinal dimer reflects an alternative metabolic/antidotal pathway of all-trans-retinal in the retina. J. Biol. Chem. 2018, 293(37), 14507-14519.

2. Zhao J, Liao Y, Chen J, Dong X, Gao Z, Zhang H, Wu X, Liu Z, and Wu Y*. Aberrant buildup of all-trans-retinal dimer, a non-pyridinium bisretinoid lipofuscin fluorophore, contributes to the degeneration of the retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 2017, 58(2), 1063-1075.

3. Li J, Zhang Y, Cai X, Xia Q, Chen J, Liao Y, Liu Z, and Wu Y*. All-trans-retinal dimer formation alleviates the cytotoxicity of all-trans-retinal in human retinal pigment epithelial cells. Toxicology 2016, 371, 41-48.

4. Liu X, Chen J, Liu Z, Li J, Yao K*, and Wu Y*. Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids. Invest. Ophthalmol. Vis. Sci. 2016, 57(3), 1017-1030.

5. Zhang J#, Bai Y#, Qi Y, Zhang Q, Li S, Huang L, Wu Y*, and Li X*. Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration. Cell Death Dis. 2015, 6, e1972.

6. Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, and Wu Y*. Involvement of endoplasmic reticulum stress in all-trans-retinal induced retinal pigment epithelium degeneration. Toxicol. Sci. 2015, 143(1), 196-208.

7. Zhao J, Yao K, Jin Q, Jiang K, Chen J, Liu Z, Li J, and Wu Y*. Preparative and biosynthetic insights into pdA2E and isopdA2E, retinal-derived fluorophores of retinal pigment epithelial lipofuscin. Invest. Ophthalmol. Vis. Sci. 2014, 55(12), 8241-8250.

8. Wu Y*, Jin Q, Yao K, Zhao J, Chen J, Wu X, Gan L, Li J, Song X, Liu X, and Cai X. Retinal metabolism in humans induces the formation of an unprecedented lipofuscin fluorophore 'pdA2E'. Biochem. J. 2014, 460(3), 343-352.

9. Li J, Yao K, Yu X, Dong X, Gan L, Luo C, and Wu Y*. Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells. J. Biol. Chem. 2013, 288(50), 35671-35682.

10. Wu Y, Zhou J, Fishkin NE, Rittman BE, and Sparrow JR. Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid. J. Am. Chem. Soc. 2011, 133(4), 849-857.

11. Wu Y, Yanase E, Feng X, Siegel M, and Sparrow JR. Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc. Natl. Acad. Sci. U.S.A. 2010, 107(16), 7275-7280.

12. Wu Y, Fishkin NE, Pande A, Pande J, and Sparrow JR. Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J. Biol. Chem. 2009, 284(30), 20155-20166.



上一篇:李炜教授课题组
Top