Yueping Zhou

Title: Professor

Degree: M.D., Ph.D.

Department: Ophthalmology and Visual Science

Research field: Corneal & Ocular Surface Diseases

Email: ypzhou1@xmu.edu.cn

Tel: +86-(0)592-2183761

1989-1992  Ph.D. in Pharmacology, The University of Tokyo, Tokyo, Japan
1983-1986  M.Sc. in Pharmacology, Graduate School of Peking Union Medical College, Beijing, China
1978-1983  M.D. (equivalent) Jiangxi Medical College, Nanchang, China

Having conducted research work in the medical science area for over two decades in well known national and international research institutions, including Johns Hopkins Medical Institutions (JHMI), New York University, University of Toronto, Tokyo University and Chinese Academy of Medical Sciences (CAMS), Dr. Zhou returned to China and joined the faculty of Xiamen University in 2008. Currently his research focus is in the basic research of ocular surface diseases, mainly the role of signaling pathway in the pathogenesis of ocular surface diseases and the discovery of new anti-inflammation, anti-angiogenesis and anti-oxidant drugs in the treatment of ocular surface diseases. Dr. Zhou is also a reviewer of international peer-reviewed journals, e.g. British Journal of Pharmacology, IOVS, etc.

Selected Publications:
(link to PubMed for all publications)

1. Zheng X, Cui H, Yin Y, Zhang Y, Zong R, Bao X, Ma JX, Liu Z, Zhou Y*. SERPINA3K Ameliorates the Corneal Oxidative Injury Induced by 4-Hydroxynonenal. Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2874-2883. doi: 10.1167/iovs.17-21544.

2. Qiu F, Liu Z, Zhou Y, He J, Gong S, Bai X, Zeng Y, Liu Z, Ma JX. Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration. Sci Rep. 2017 Apr 28;7(1):1263. doi: 10.1038/s41598-017-01119-2.

3. Zhou J, Ge L, Jia C, Zheng X, Cui H, Zong R, Bao X, Yin Y, Ma JX, Li W, Liu Z, Zhou Y* ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress. Sci Rep. 2016 Nov 2;6:36481. doi: 10.1038/srep36481.

4. Chen Y, Yang W, Zhang X, Yang S, Peng G, Wu T, Zhou Y, Huang C, Reinach PS, Li W, Liu Z. MK2 inhibitor reduces alkali burn-induced inflammation in rat cornea. Sci Rep. 2016 Jun 22;6:28145.

5. Zong R, Zhou T, Lin Z, Bao X, Xiu Y, Chen Y, Chen L, Ma JX, Liu Z, Zhou Y* Down-Regulation of MicroRNA-184 Is Associated With Corneal Neovascularization. Invest Ophthalmol Vis Sci. 2016 Mar 1;57(3):1398-407.

6. Chen L, Zong R, Zhou J, Ge L, Zhou T, Ma JX, Liu Z, Zhou Y*  The Oxidant Role of 4-Hydroxynonenal in Corneal Epithelium. Sci Rep. 2015 May 29(5):10630.

7. Xu Y, Zhang LY, Zou DL, Liu Z, Shang XM, Wu H, Zhou Y, He H, Liu ZG   Differential expression and function of survivin during the progress of pterygium. Invest Ophthalmol Vis Sci. 2014 Nov 12 55(12):8480-8487.

8. Zhu C, Pan F, Ge L, Zhou J, Chen L, Zhou T, Zong R, Xiao X, Dong N, Yang M, Ma JX, Liu Z, Zhou Y* SERPINA3K Plays Antioxidant Roles in Cultured Pterygial Epithelial Cells through Regulating ROS System. PLoS One 2014 Oct 8;9(10):e108859.

9. Lin Z, Zhou Y, Wang Y, Zhou T, Li J, Luo P, He H, Wu H, Liu ZG. Serine Protease Inhibitor A3K Suppressed The Formation of Ocular Surface Squamous Metaplasia in a Mouse Model of Experimental Dry Eye. Invest Ophthalmol Vis Sci. 2014 Aug 7. 55(9):5813-20.

10. Zhou T, Chen L, Huang CH, Lin Z, Zong R, Zhu C, Pan F, Ma JX, Liu ZG, Zhou Y* Serine Proteinase Inhibitor SERPINA3K Suppresses Corneal Neovascularization via Inhibiting Wnt Signaling and VEGF. Invest Ophthalmol Vis Sci. 2014 Jul 15. 55(8):4863-72.

11. Qiu F, He J, Zhou Y, Bai X, Wu G, Wang X, Liu Z, Chen Y, Ma JX, Liu Z. Plasma and vitreous fluid levels of Dickkopf-1 in patients with diabetic retinopathy. Eye (Lond). 2014 Apr; 28(4):402-9.

12. Liu X, Zhang B, McBride JD, Zhou K, Lee K, Zhou Y, Liu Z, Ma JX. Anti-angiogenic and anti-neuroinflammatory effects of kallistatin through interactions with the canonical Wnt pathway. Diabetes. 2013; 62(12):4228-38.

13. Liu X, McBride J, Zhou Y, Liu Z, Ma JX. Regulation of Endothelial Progenitor Cell Release by Wnt Signaling in Bone Marrow. Invest Ophthalmol Vis Sci. 2013;54(12):7386-94.

14. Xiao X, Luo P, Zhao H, Chen J, He H, Xu Y, Lin Z, Zhou Y, Xu J, Liu Z. Amniotic Membrane Extract Ameliorates Benzalkonium Chloride-induced Dry Eye in a Murine Model. Exp Eye Res. 2013;115:31-40.

15. Hu J, Zhang Z, Chen L, Xie H, Zhou Y, Chen W, Liu Z. Serine protease inhibitor A3K protects rabbit corneal endothelium from barrier function disruption induced by TNF-α. Invest Ophthalmol Vis Sci. 2013;54(8):5400-7.

16. Xu K, Tao T, Jie J, Lu X, Li X, Mehmood MA, He H, Liu Z, Xiao X, Yang J, Ma JX, Li W, Zhou Y*, Liu Z*. Increased importin 13 activity is associated with the pathogenesis of pterygium. Mol Vis. 2013;19:604-13.

17. Zhou T, Zong R, Zhang Z, Zhu C, Pan F, Xiao X, Liu Z, He H, Ma JX, Liu Z*, Zhou Y*. SERPINA3K protects against oxidative stress via modulating ROS generation/degradation and KEAP1-NRF2 pathway in the corneal epithelium. Invest Ophthalmol Vis Sci. 2012;53(8):5033-43.

18. Han Y, Shao Y, Lin Z, Quyang L, Wang H, Zhou Y, Chen W, Chen Y, Chen WL, Hu FR, Li W, Liu Z. Netrin-1 Simultaneously Suppresses Corneal Inflammation and Neovascularization. Invest Ophthalmol Vis Sci. 2012; 53(3):1285-95.

19. Xiao X, He H, Lin Z, Luo P, He H, Zhou T, Zhou Y, Liu Z. Therapeutic effects of epidermal growth factor on benzalkonium chloride-induced dry eye in a mouse model. Invest Ophthalmol Vis Sci. 2012;53(1):191-7.

20. Liu X, Lin Z, Zhou T, Zong R, He H, Liu Z, Ma JX, Liu Z*, Zhou Y*. Anti-angiogenic and Anti-inflammatory Effects of SERPINA3K on Corneal Injury PLoS One. 2011; 6(1): e16712.

21. Zhou Y, Liu Q, Zhou T, Lin Z, Zong R, Liu Z, Sun F, Shao Y, Liu X, Ma JX, Liu Z.  Modulation of the Canonical Wnt Pathway by Benzalkonium Chloride in Corneal Epithelium. Exp Eye Res. 2011; 93(4): 355-362.

22. Wang H, Tao T, Tang J, Mao YH, Li W, Peng J, Tan G, Zhou YP, Zhong JX, Tseng SC, Kawakita T, Zhao YX, Liu ZG.  Importin 13 Serves as a Potential Marker for Corneal Epithelial Progenitor Cells. Stem Cells. 2009;27(10):2516-2526.