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教师队伍
邱彦

职称:教授/博导

学科:眼科药理学

研究方向:内源性脂质代谢与调控

邮箱:yanqiu@xmu.edu.cn

个人简历:

教育背景:

1996-2000    江西中医学院药学系,本科

2000-2005    沈阳药科大学中药学院,博士

2001-2005    北京大学医学部天然药物及仿生药物国家重点实验室,联合培养

 

工作经历:

2005.08-2009.07 厦门大学医学院,讲师

2009.08-2016.07 厦门大学医学院,副教授

2015.06-2016.06 意大利罗马第一大学药理学系,访问学者

2016.07-至今       厦门大学医学院,教授

 

主要研究领域:

内源性脂质代谢和调控,包括基于N-酰基乙醇胺水解酸酰胺酶(NAAA)的药物开发;内源性脂肪酰基乙醇胺的药效学及作用机制研究;调控脂质微环境在炎症、肿瘤等疾病中的应用等。

 

主要学术成果:

全部论文:pubmed

 

代表论文:

1. Yuhang Li, Pan Zhou, Huixia Chen, Qi Chen, Xiaofei Kuang, Canzhong Lu*, Jie Ren, and Yan Qiu*, Inflammation-restricted anti-inflammatory activities of a N-acylethanolamine acid amidase (NAAA) inhibitor F215, Pharmacological Research, 2018, 1323, 7-14.

2. Yuhang Li, Qi Chen, Longhe Yang, Yanting Li, Yang Zhang, Yan Qiu*, Jie Ren,  Canzhong Lu*, Identification of highly potent N-acylethanolamine acid amidase (NAAA) inhibitors: Optimization of the terminal phenyl moiety of oxazolidone derivatives, European Journal of Medicinal Chemistry, 2017, 139, 214-221.

3. Yan Qiu†, Jie Ren†, Hongwei Ke, Yang Zhang, Qi Gao, Longhe Yang, Canzhong Lu* and Yuhang Li*, Design and synthesis of uracil urea derivatives as potent and selective fatty acid amide hydrolase inhibitors, RSC Advances, 2017, 7, 22699-22705.

4. Jie Ren, Yuhang Li*, Hongwei Ke, Yanting Li, Longhe Yang, Helin Yu, Rui Huang, Canzhong Lu, and Yan Qiu*, Design, synthesis, and biological evaluation of oxazolidone derivatives as highly potent N-acylethanolamine acid amidase (NAAA) inhibitors, RSC Advances, 2017,7, 12455-12463.

5. Yan Qiu*, Yang Zhang, Yuhang Li, Jie Ren, Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase, Molecules, 2016, 21, 229; doi:10.3390/molecules21020229.

6. Ling Chen, Jie Ren, Longhe Yang, Yanting Li, Jin Fu, Yuhang Li, Yifeng Tian, Funan Qiu, Zuguo Liu*, Yan Qiu*, Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis, Scientific Reports, 2016, 6, 19665; doi: 10.1038/srep19665.

7. Longhe Yang†, Long Li†, Ling Chen, Yanting Li, Huixia Chen, Yuhang Li, Guangnian Ji, Donghai Lin, Zuguo Liu*, Yan Qiu*, Potential analgesic effects of a novel N-acylethanolamine acid amidase inhibitor F96 through PPAR-α, Scientific Reports, 2015, 5, 13565; doi: 10.1038/srep13565.

8. Long Li, Lei Li, Ling Chen, Xiaoyu Lin, Yaping Xu, Jie Ren, Jin Fu, Yan Qiu*, Effect of Oleoylethanolamide on Diet-induced Nonalcoholic Fatty Liver in Rats, Journal of Pharmacological Sciences, 2015, 127, 244-250.

9. Longhe Yang, Yanting Li, Jie Ren, Chenggang Zhu, Jin Fu, Donghai Lin*, Yan Qiu*, Celastrol Attenuates Inflammatory and Neuropathic Pain Mediated by Cannabinoid Receptor Type 2, International Journal of Molecular Sciences, 2014, 15, 13637-13648.

10. Ling Chen†, Baoying Xie†, Lei Li, Weizhong Jiang, Yang Zhang, Jin Fu, Guoxian Guan, Yan Qiu*, Rapid and Sensitive LC-MS/MS Analysis of Fatty Acids in Clinical Samples, Chromatographia, 2014, 77, 1241-1247.

11. Xiyue Wu, Lijun Han, Xiaolin Zhang, Long Li, Changzhen Jiang, Yan Qiu, Rui Huang, Baoying Xie, ZhiXiong Lin, Jie Ren*, Jin Fu*, Alteration of endocannabinoid system in human gliomas, Journal of Neurochemistry, 2012,120 (5), 842-849.

 

主持课题:

1. 国家自然科学基金,新型NAAA抑制剂的分子构建及非依赖性抗神经痛作用研究(81373273),2014.1-2017.12;

2. 南方海洋研究中心项目,外周型镇痛类海洋生物碱衍生物的临床前开发(14GYY018NF18),2014.10-2016.12;

3. 厦门大学校长基金,系统性抑制NAAA治疗神经病理性疼痛的新靶标验证及机制研究(20720150054),2015.01-2016.12;

4. 国家自然科学基金,基于NAAA-PEA途径的新型镇痛类先导化合物设计、合成及评价(81273371),2013.1-2013.12;

5. 厦门市科技局项目,归夏消斑通血颗粒的药学研究(3502Z20113010),2011.1-2013.12;

6. 福建省自然科学基金,东方肉穗草中芳香酰化黄酮作为新型补体抑制剂的研究(2009J05088),2009.5-2011.12;

7. 国家自然科学基金,Dysidea属海绵中倍半萜/(氢)醌类化合物抗艾滋病病毒的物质基础及其作用机理(30600053),2007.1-2009.12

 

专利:

1. 一类取代杂环衍生物及其制备方法,邱彦,李宇航,任杰,杨隆河,朱程刚,专利号:ZL 201410603721.

2. 一类取代杂环衍生物在制备治疗疼痛药物中的应用,邱彦,杨隆河,任杰,李宇航,朱程刚,专利号:ZL 201410604001.7;

3. 利用小分子化合物诱导干细胞向心肌分化的方法,徐秀琴,邱彦,刘靖,林瑜,专利号:ZL 201410629278.5。

 

 

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