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Name: Zuguo Liu
Title: Dean, Professor, Director
Degree: M.D., Ph.D.
Department: Department of Ophthalmology & Visual Science, Eye Institute of Xiamen University
Research field: Corneal & Ocular Surface Diseases, Corneal Tissue Engineering
TEL: +86-592-2183761
Email: zuguoliu@xmu.edu.cn
Profile:
Zuguo Liu, Professor of Ophthalmology, is currently the dean of Medical School and the director of both Eye Institute and Cancer Institute of Xiamen University. He was awarded as Chang Jiang Scholar by Ministry of Education, Distinguished Young Scholar by National Natural Science Foundation, State-level Talents by Ministry of Personnel and Chinese Academy of Sciences.


Professor Liu received his M.D. degree from Hengyang Medical College in Hunan in 1985,   and obtained his M.S. and Ph.D. degree at Sun Yat-sen Medical University of China in 1991 and 1996 respectively. From 1991 to 2002, he performed his medical practice in Zhongshan Ophthalmic Center, Sun Yat-sen University. During this period, he firstly studied as a visiting scholar at LSU eye center in 1992, and then he worked as a post-doc fellow at Bascom Palmer Eye Institute, University of Miami from 1997 to 1999 in the United States. Between 2000 and 2001, he was on secondement to Peking University Eye Center to assume the positions as the vice-director of Linhu Eye Hospital and the dean of Eye Institute. He was the vice-director of Zhongshan Ophthalmic Center and the dean of both Optometry Department and Ocular Surface Disease Institute of Sun Yat-sen University from 2003 to 2005. Starting from 2006, he moved to Xiamen University, and promoted as the dean of Medical School of Xiamen University as well as the director of Eye Institute of Xiamen University. He began to function as the party standing committee member of Xiamen University from 2013.  


Professor Liu has been engaged in clinical and basic research of Ophthalmology for a long time. He is an eminent ophthalmic clinician who started and established the area of ocular surface disease and dry eye in China. In addition, he is the health care specialist for central committee members. He was the first surgeon to produce acellular swine cornea and successfully use them to perform Lamellar Keratoplasty in patients, which is regarded as one of the breakthrough in medical science globally in recent years. In 1999 he discovered and suggested the idea that dry eye could lead to the alterations in vision, which fundamentally changed the traditional opinions of dry eye. Therefore, this idea is listed as one of the three major progresses in dry eye area for last decade, and was adopted into the new definition of dry eye in the international dry eye workshop (DEWS 2007). As a pioneer, he proposed the classification methods and standards of color-coded map of whole corneal thickness in 1999. So far, this color-coded map is still the sole criteria and widely applied all over the world.  


Professor Liu has issued 26 national textbooks and monographs as chief editor or editor. He published more than 340 academic papers with 120 papers in SCI journals. Among them, 27 papers were published in IOVS and Ophthalmology, the best journals in basic and clinical research of Ophthalmology, as well as 64 papers in Chinese Journal of Ophthalmology. These articles were cited over 2500 times by SCI journals, and his H-index is tied for first place in China. He has been granted with the 2nd Prize of National Science and Technology Advance Awards for three times(one as the first participant, and two as the second participant), the 1st Prize of Ministerial and Provincial Science and Technology Advance Awards for seven times (five times as the first participant).  He invented 10 patents, and he has been supported by more than 50 grants from Development Program of China (973 and 863 key programs) and National Natural Science Funds. He is the winner of Chinese Youth Technology Award, Wuxi Medicinal Chemistry Research Award, the mid-aged and young talents with outstanding contributions awards from ministry of health, the state council special allowance, the distinguished award of Ophthalmology in China, and APAO ophthalmic achievement award.


Currently, Professor Liu is the routine director and chairman of ophthalmology branch of association for pharmaceutical and health exchanges across the Taiwan straits, vice-president of Asia dry eye society, member of the council of Asian cornea society, as well as the standing committee of four professional associations including Chinese medical association and Chinese medical doctor association. He is the deputy editor of three professional journals including Chinese Journal of Ophthalmology, and the director of Fujian key laboratory of eye and visual science.  

Publications

(link to PubMed for all publications)


1. Hua Wang, Tao Tao, Jing Tang, Yihui Mao, Wei Li, Juan Peng, Gang Tan, Jingxiang Zhong, Scheffer C.G. Tseng, Tetsuya Kawakita,  Yongxiang Zhao, Zuguo Liu (corresponding). Importin 13 serves as a potential marker for human corneal epithelial progenitor cell. Stem Cell,2009 , 27(Jul 10). 2516-2526.


2. Zuguo Liu (corresponding), Wei Li, Lingyi Liang, Jing Liu. Porcine Corneal Equivalent for Xenographs. Science. 2012, sup P24-26.


3. Liu X, Zhang B, McBride JD, Zhou K, Lee K, Zhou Y, Liu Z(corresponding), Ma JX. Anti-angiogenic and anti-neuro inflammatory effects of kallistatin through interactions with the canonical Wnt pathway. Diabetes. 2013 Dec; 62(12): 4228-38.


4. Qiuping Liu, Jingming Li, Rui Cheng, Ying Chen, Kyungwon Lee, Yang Hu, Jinglin Yi, Zuguo Liu (corresponding), Jianxing Ma. Nitrosative Stress Plays an Important Role in Wnt Pathway Activation in Diabetic Retinopathy. Antioxidants & Redox Signaling. 2013 Apr 1; 18(10): 1141-53.


5. Huang C, Wang H, Pan J, Zhou D, Chen W, Li W, Chen Y, Liu Z (corresponding). Benzalkonium chloride induces subconjunctival fibrosis through the COX-2-modulated activation of a TGF-β1/Smad3 signaling pathway. Invest Ophthalmol Vis Sci. 2014 Nov 18;55(12): 8111-22.


6. Zhen Zhang, WenZhao Yang, ZhenZhen Zhu, QianQian Hu, YanFeng Chen, Hui He,Yong-Xiong Chen, and ZuGuo Liu  (corresponding).Therapeutic Effects of  Topical Doxycycline in a Benzalkonium Chloride–Induced Mouse Dry Eye Model.Invest  Ophthalmol Vis Sci. 2014 May 6;55(5):2963-74.


7. Yang L, Li L, Chen L, Li Y, Chen H, Li Y, Ji G, Lin D, Liu Z(corresponding).Qiu Y.Potential analgesic effects of a novel N-acylethanolamine acid amidase inhibitor F96 through PPAR-alpha. Sci Rep. 2015 Aug 27;5:13565.


8. Dong, F., Liu, C. Y., Yuan, Y., Zhang, Y., Li, W., Call, M., Zhang, L., Chen, Y., Liu, Z(corresponding)., & Kao, W. W.Perturbed meibomian gland and tarsal plate morphogenesis by excess TGF alpha in eyelid stroma. Dev Biol(3.547), 2015 Oct 15;406(2):147-57.


9. Zhang L, Zou D, Li S, Wang J, Qu Y, Ou S, Jia C, Li J, He H, Liu T, Yang J, Chen Y, Liu Z(corresponding), Li W. An Ultra-thin Amniotic Membrane as Carrier in Corneal Epithelium Tissue-Engineering. Sci Rep. 2016 Feb 15;6:21021.


10. Chen Y, Yang W, Zhang X, Yang S, Peng G, Wu T, Zhou Y, Huang C, Reinach PS, Li W, Liu Z(corresponding). MK2 inhibitor reduces alkali burn-induced inflammation in rat cornea. Sci Rep. 2016 Jun 22;6:28145.


11. Hong J, Zhong T, Li H, Xu J, Ye X, Mu Z, Lu Y, Mashaghi A, Zhou Y, Tan M, Li Q, Sun X, Liu Z(corresponding), Xu J.Ambient air pollution, weather changes,and outpatient visits for allergic conjunctivitis: A retrospective registry study. Sci Rep. 2016 Apr 1;6:23858.


12. Wang YC, Li S, Chen X, Ma B, He H, Liu T, Yu J, Zhang L, Chen Y, Liu Z(corresponding), Li W. Meibomian Gland Absence Related Dry Eye in Ectodysplasin A Mutant Mice. Am J Pathol. 2016 Jan;186(1):32-42.



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