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刘祖国教授课题组


 

成员:
教授:  刘祖国
副教授:张晓博
博士后:李正日
技术员:黄彩虹
研究生:吴漾,陈艳丰,林祥,杨舒,彭高,唐丽颖,杨启晨,朱莉
电话:0592-2183761
邮箱:zuguoliu@xmu.edu.cn
 
研究方向:
泪膜及干眼研究方向
泪液来源于泪腺及眶周附属腺体,在眼表形成泪膜,营养、润滑和保护角结膜上皮细胞。当各种原因导致泪膜受损时,除了引起不适症状外,还可造成眼表炎症、上皮细胞凋亡、鳞状上皮化生、杯状细胞减少等病理改变,严重者出现角膜溃疡及新生血管,对视力造成永久性损害。 
我国干眼发病率高,约占人口的20-30%,严重影响国人生活质量。厦门大学眼科研究所一直致力于干眼流行病学、发病机制、动物模型、药物筛选、治疗手段的研究,获得了国家及省部级多项科研基金资助,承担和参与了国内外大型多中心临床研究任务,并利用基础与临床紧密结合的优势,在多中心研究中发挥关键作用。经过多年研究,我们在国际上首次建立了模拟干眼病理学改变的组织培养模型,建立了新型的大鼠及兔干眼动物模型,在国内外眼科杂志上发表了一系列高水平文章,并申请了多项国家发明专利。

 

角膜组织工程研究方向

中国现有角膜病致盲患者约400万人,然而,由于角膜供体极度匮乏,目前我国每年只能实施角膜移植手术3000余例,角膜组织供需关系极度紧张。因此,角膜组织替代物,亦即组织工程角膜 (Tissue engineered cornea) 的研制与应用,具有很重要的现实意义。
厦门大学眼科研究所致力于角膜组织工程研究,在组织工程角膜上皮、异种组织工程角膜基质以及组织工程角膜内皮的构建方面均有研究计划,研究项目得到了国家高技术研究发展计划(863计划)以及国家自然科学基金的资助。近3年,在组织工程角膜上皮构建方法的优化,异种角膜基质组织的脱细胞方法,异种组织工程角膜基质的有效性评估等方面取得了重要进展。2012年4月,Science杂志增刊报道了眼科研究所采用猪来源的板层角膜移植给人类,成为世界上第一次公开报道成功实施猪角膜向人类的异种移植。未来将在成分组织工程角膜研究的基础上开展组织工程全角膜的研究。

近期发表的部分论文:

1、Chen L, Ren J, Yang L, Li Y, Fu J, Li Y, Tian Y, Qiu F, Liu Z*, Qiu Y*.Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis.Sci Rep. 2016 Jan 27;6:19665.


2、Wang YC, Li S, Chen X, Ma B, He H, Liu T, Yu J, Zhang L, Chen Y, Liu Z*, Li W*. Meibomian Gland Absence Related Dry Eye in Ectodysplasin A Mutant Mice. Am J Pathol. 2016 Jan;186(1):32-42.


3、Li J, Li C, Wang G, Liu Z, Chen P, Yang Q, Dong N, Wu H, Liu Z*, Li W*.APR-246/PRIMA-1Met Inhibits and Reverses Squamous Metaplasia in Human Conjunctival Epithelium. Invest Ophthalmol Vis Sci. 2016 Feb 1;57(2):444-52.


4、Zhang L, Zou D, Li S, Wang J, Qu Y, Ou S, Jia C, Li J, He H, Liu T, Yang J, Chen Y, Liu Z*, Li W*.An Ultra-thin Amniotic Membrane as Carrier in Corneal Epithelium Tissue-Engineering.Sci Rep. 2016 Feb 15;6:21021.


5、Hong J, Zhong T, Li H, Xu J, Ye X, Mu Z, Lu Y, Mashaghi A, Zhou Y, Tan M, Li Q, Sun X, Liu Z*, Xu J*.Ambient air pollution, weather changes, and outpatient visits for allergic conjunctivitis: A retrospective registry study.Sci Rep. 2016 Apr 1;6:23858.


6、Chen Y, Yang W, Zhang X, Yang S, Peng G, Wu T, Zhou Y, Huang C, Reinach PS, Li W,, Liu Z*,.MK2 inhibitor reduces alkali burn-induced inflammation in rat cornea.Sci Rep. 2016 Jun 22;6:28145.


7、Qu Y, Chi W, Hua X, Deng R, Li J, Liu Z*, Pflugfelder SC, Li DQ*.Unique expression pattern and functional role of periostin in human limbal stem cells. PLoS One. 2015 Feb 6;10(2):e0117139.


8、Chen Y, Deng F, Zheng J, YinJ, Huang R, Liu W, Lin Q, Gao Y, Gao X, Yu X, Liu Z*, Chen J*.High circulating level of interleukin-18 in patients with primary Sjögren's syndrome is associated with disease activity.Mod Rheumatol. 2015 Mar 24:1-3.


9、Jiemin Zhu,He Hong-Gu,Xiuzhu Zhou,Haixia Wei, Yaru Gao,Benlan Ye, Zuguo Liu*,Sally Wai-Chi Chan*. Pain relief effect of breast feeding and music therapy during heel lance for healthy-term neonates in China: A randomized controlled trial.Midwifery.2015 Mar;31(3):365-72.


10、Han Y, Shao Y, Liu T, Qu YL, Li W, Liu Z*. Therapeutic effects of topical netrin-4 inhibits corneal neovascularization in alkali-burn rats.PLoS One. 2015 Apr 8;10(4):e0122951.


11、Yun Han, Yi Shao, TingTing Liu, SangMing Li, Wei Li, ZuGuo Liu*. Therapeutic effects of topical Netrin4 in a corneal acute inflammatory model.Int J Ophthalmol. 2015 Apr 18;8(2):228-33.


12、Hong J, Yu Z, Jiang C, Zhou X, Liu Z*, Sun X, Xu J*. Corvis ST Tonometer for Measuring Postoperative IOP in LASIK Patients.Optom Vis Sci. 2015 May;92(5):589-95.


13、Deng, F, Chen J, Zheng J, Chen Y, Huang R, Yin J, Gao, X., Lin Q, Huang C, Gao Y, Yu X*, &LiuZ*. Association of BAFF and IL-17A with subphenotypes of primary Sjogren's syndrome. Int J Rheum Dis. 2015 May 4.


14、Poon MW, He J, Fang X, Zhang Z, Wang W, Wang J, Qiu F, Tse HF, Li W, Liu Z*, Lian Q*. Human Ocular Epithelial Cells Endogenously Expressing SOX2 and OCT4 Yield High Efficiency of Pluripotency Reprogramming. PLoS One. 2015 Jul 1;10(7):e0131288.


15、Yang L, Li L, Chen L, Li Y, Chen H, Li Y, Ji G, Lin D, Liu Z*.Qiu Y*.Potential analgesic effects of a novel N-acylethanolamine acid amidase inhibitor F96 through PPAR-alpha. Sci Rep. 2015 Aug 27;5:13565.


16、Liu Z, Qiu F, Li J, Zhu Z, Yang W, Zhou X, An J, Huang F, Wang Q, Reinach PS, Li W, Chen W, Liu Z*. Adenomatous polyposis coli mutation leads to myopia development in mice. Plos ONE. 2015 Oct 23;10(10):e0141144.


17、Dong, F, Liu, C Y, Yuan, Y, Zhang, Y, Li, W, Call, M, Zhang, L, Chen, Y, Liu, Z*, & Kao, WW*. Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFalpha in eyelid stroma. Dev Biol, 2015 Oct 15;406(2):147-57.


18、Shao Y, Tang J, Zhou Y, Qu Y, He H, Liu Q, Tan G, Li W*, Liu Z*. A novel method in preparation of acellular porcine corneal stroma tissue for lamellar keratoplasty. Am J Transl Res. 2015 Dec 15;7(12):2612-29.


19、Chen J, Dong F, Chen W, Sun X, Deng Y, Hong J, Zhang M, Yang W, Liu Z*, Xie L*.Clinical efficacy of 0.1% pranoprofen in treatment of dry eye patients: a multicenter, randomized, controlled clinical trial.Chin Med J (Engl). 2014;127(13):2407-12.


20、Qiu F, He J, Zhou Y, Bai X, Wu G, Wang X, Liu Z, Chen Y, Ma JX*, Liu Z*.Plasma and vitreous fluid levels of Dickkopf-1 in patients with diabetic retinopathy. Eye (Lond). 2014 Apr;28(4):402-9.


21、Zhen Zhang#, Wen-Zhao Yang#, Zhen-Zhen Zhu, Qian-Qian Hu, Yan-Feng Chen, Hui He,Yong-Xiong Chen, and Zu-Guo Liu*.Therapeutic Effects of Topical Doxycycline in a Benzalkonium Chloride–Induced Mouse Dry Eye Model.Invest Ophthalmol Vis Sci. 2014 May 6;55(5):2963-74.


22、Lin Z, Zhou Y, Wang Y, Zhou T, Li J, Luo P, He H, Wu H*, Liu Z*.Serine protease inhibitor A3K suppressed the formation of ocular surface squamous metaplasia in a mouse model of experimental dry eye.Invest Ophthalmol Vis Sci. 2014 Aug 7;55(9):5813-20.


23、Ma J, Zhou D, Fan M, Wang H, Huang C, Zhang Z, Wu Y, Li W, Chen Y*, Liu Z*.Keratocytes create stromal spaces to promote corneal neovascularization via MMP13 expression.Invest Ophthalmol Vis Sci. 2014 Sep 4;55(10):6691-703.


24、Zhang Z, Huang Y, Xie H, Pan J, Liu F, Li X, Chen W, Hu J*, Liu Z*.Benzalkonium chloride suppresses rabbit corneal endothelium intercellular gap junction communication.PLoS One. 2014 Oct 9;9(10):e109708.


25、Huang C#, Wang H#, Pan J, Zhou D, Chen W, Li W, Chen Y*, Liu Z*.Benzalkonium chloride induces subconjunctival fibrosis through the COX-2-modulated activation of a TGF-β1/Smad3 signaling pathway.Invest Ophthalmol Vis Sci. 2014 Nov 18;55(12):8111-22.


26、Xu YX, Zhang LY, Zou DL, Liu ZS, Shang XM, Wu HP, Zhou Y, He H, Liu ZG*. Differential expression and function of survivin during the progress of pterygium. Invest Ophthalmol Vis Sci. 2014 Dec 2;55(12):8480-7.

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