当前位置:主页 > 中文 > 课题组 > 李程课题组
李程课题组


 
课题组成员:
副教授: 李程
研究助理王国良
研究生:陈佩,杨启晨,申眉,王炎子
Tel: 0592-2183761
E-mail: dimplelc@gmail.com
 
主要研究领域:
角膜和眼表疾病的发生机理及调控机制
角膜上皮干细胞,作为角膜上皮的唯一细胞来源,对维持角膜上皮的动态稳定和角膜透明性发挥着极其重要的作用。角膜上皮干细胞功能障碍(limbal stem cell dysfunction,LSCD)的患者由于干细胞数量的缺乏或定向分化潜能丢失,往往表现为眼表组织广泛破坏,发生持续性角膜上皮缺损、慢性炎症、角膜上皮结膜化和新生血管侵入,继而角膜透明度下降,造成患者严重视力障碍甚至失明。大量研究证明,p38MAPK, Wnt, Notch等多种信号传导通路参与并调节了LSCD的发生进程。深入研究多条通路之间交叉作用的具体机制,必将为我们认识角膜上皮干细胞的生物学特性,阐明LSCD的发病机理提供重要信息。

 
角膜上皮干细胞增殖分化的相关信号通路以及LSCD发生的可能机制
代表性论文:
1、Li J#, Li C#, Wang G, Liu Z, Chen P, Yang Q, Dong N, Wu H, Liu Z*, Li W*. APR-246/PRIMA-1Met Inhibits and Reverses Squamous Metaplasia in Human Conjunctival Epithelium. Invest Ophthalmol Vis Sci. 2016, 57(2):444-52.


2、Li C, Dong N, Wu H, Dong F, Xu Y, Du H, He H, Liu Z*, Li W*. A novel method for preservation of human corneal limbal tissue. Invest Ophthalmol Vis Sci. 2013, 54(6), 4041-4047.


3、Li C, Dong F, Jia Y, Du H, Dong N, Xu Y, Wang S, Wu H, Liu Z*, Li W*. Notch signal regulates corneal endothelial-to-mesenchymal transition. Am J Pathol. 2013, 183(3), 786-795.


4、Li C, Yin T, Dong N, Dong F, Fang X, Qu YL, Tan Y, Wu H, Liu Z*, Li W*. Oxygen tension affects terminal differentiation of corneal limbal epithelial cells. J Cell Physiol. 2011, 226(9), 2429-2437.


5、Dong N, Qin W, Xue Y, Li C*, Liu Z*. Hypoxia affects in vitro proliferation and differentiation of mouse corneal epithelial progenitor cell. In Vitro Cell Dev Biol Anim. 2013, 49(7), 508-514.


6、Dong N#, Li C#, Chen W, Qin W, Xue Y, Wu H, Fibrin glue-assisted for the treatment of corneal perforations using glycerin-cryopreserved corneal tissue, Int J Ophthalmol, 2014, 7(1), 62-65.


7、Shao Y, Yu Y, Zhou Q, Li C, Yang L, Pei CG. Inhibition of miR-134 Protects Against Hydrogen Peroxide-Induced Apoptosis in Retinal Ganglion Cells. J Mol Neurosci. 2015, 56(2):461-71.


8、Lin H, Qu Y, Geng Z, Li C, Wu H, Dong N, Liu Z*, Li W*.  Air exposure induced characteristics of dry eye in conjunctival tissue culture. PLoS One. 2014, 9(1), e87368.


9、Tan Y, Qiu F, Qu YL, Li C, Shao Y, Xiao Q, Liu Z*, Li W*. Amniotic membrane inhibits squamous metaplasia of human conjunctival epithelium. Am J Physiol Cell Physiol. 2011, 301(1), C115-125.


10、Dong N, Li W, Lin H, Wu H, Li C, Chen W, Qin W, Quyang L, Wang H, Liu Z. Abnormal epithelial differentiation and tear film alteration in pinguecula. Invest Ophthalmol Vis Sci. 2009, 50(6):2710-5.

© 2015-2016厦门大学眼科研究所