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陈永雄  

 

职称:教授/博导

学科(专业):眼科学

研究方向:新生血管性眼病及角膜免疫

邮箱:yxchen1962@xmu.edu.cn

电话:0592-2183761

 

教育背景:

1980-1985 福建医学院 临床医学系 学士

1988-1991 中山医科大学组织胚胎学教研室 组织胚胎学 硕士

1993-1996 中山医科大学附属第一医院 内科学 博士

 

工作经历:

1985.07-1988.07 福建医学院组织胚胎学教研室 助教

1991.07-2003.07 中山医科大学附属第一医院肾内科 副研究员

1999.11-2001.02 香港大学内科系 研究助理

2001.03-2001.11 美国贝勒医学院内科系 博士后 

2001.11-2002.07 美国范特比尔特大学医学中心遗传医学系博士后

2002.07-2006.10 香港大学外科系 博士后

2006.10-2007.10 英国帝国理工大学生物外科和生物技术系高级研究员

2007.10-2009.09 美国新泽西州立大学细胞生物学和神经科学系高级研究员

2009.10-至今       厦门大学医学院 教授

 

主要研究领域:

主要研究领域为新生血管性眼病及角膜免疫,包括新生血管性眼病的发病机制及治疗;角膜免疫的机制。

 

发表文章:

1. Wang Y, Li S, Chen X, MaB, He H, Liu T, Yu J, Zhang L, Chen Y, LiuZ, Li W. Meibomian Gland Absence Related Dry Eye in Ectodysplasin A MutantMice. Am J Pathol. 2016 Jan;186(1):32-42.

 

2. Wu SG, Rao MY, Zhou J, Lin Q, Wang ZJ, ChenYX*, He ZY*. Distribution of metastatic disease in the brain in relationto the hippocampus: a retrospective single-center analysis of 6064 metastasesin 632 patients. Oncotarget. 2015 Dec 22;6(41):44030-6.

 

3. Dong F,Liu CY,Yuan Y,Zhang Y,Li W, Call M,ZhangL,Chen Y,Liu Z,Kao WW. Perturbed meibomian gland and tarsal platemorphogenesis by excess TGFα in eyelid stroma.Dev Biol.2015 Oct 15;406(2):147-57.

 

4. Wang X, Cao K, Sun X, ChenY, Duan Z, Sun L, Guo L, Bai P, Sun D, FanJ, He X, Young W, Ren Y. Macrophages in spinal cord injury:Phenotypic and functional change from exposure to myelindebris. Glia. 2015 Apr;63(4):635-51.

 

5. Huang C, Wang H, Pan J, ZhouD, Chen W, Li W, Chen Y*, Liu Z*. Benzalkonium Chlorideinduces Subconjunctival Fibrosis through the COX-2- modulated activation of aTGF-β1/Smad3 Signaling Pathway. Invest Ophthalmol Vis Sci. 2014 Nov18;55(12): 8111-8122.

 

6. Ma J, Zhou D, Fan M, Wang H, Huang C, Zhang Z,Wu Y, Li W, Chen Y*, Liu Z*. Keratocytes Create Stromal Spaces toPromote Corneal Neovascularization Via MMP13 Expression. InvestOphthalmol Vis Sci. 2014 Sep 4;55(10):6691-703.

 

7. Zhang Z, Yang WZ, Zhu ZZ, Hu QQ, Chen YF, HeH, Chen Y, Liu ZG.Therapeutic Effects of Topical Doxycycline in aBenzalkonium Chloride-Induced Mouse Dry Eye Model. Invest Ophthalmol VisSci. 2014 May 6;55(5):2963-74.

 

8、Chen Y, Hwang SL, Chan VS, Chung NP, Wang SR, Li Z, Ma J, LinCW, Hsieh YJ, Chang KP, Kung SS, Wu YC, Chu CW, Tai HT, Gao GF, Zheng B, Yokoyama KK,Austyn JM, Lin CL. Binding of HIV-1 gp120 to DC-SIGNpromotes ASK-1-dependent activation-induced apoptosis of humandendritic cells. PLoS Pathogens. 2013;9(1):e1003100.

 

9. Wang XQ, Lo CM, Chen L, Cheung CK, YangZF, Chen YX, Ng MN, Yu WC, Ming X, Zhang W, Ho DW, Chan SC, FanST.Hematopoietic chimerism in liver transplantation patients and hematopoieticstem/progenitor cells in adult human liver. Hepatology. 2012Oct;56(4):1557-66.

 

10. Chen W, Hu J, Zhang Z, Chen L, Xie H, Dong N,Chen Y, Liu Z. Localization and Expression of Zonula Occludins-1 in theRabbit Corneal Epithelium following Exposure to BenzalkoniumChloride. PLoS One.2012;7(7):e40893.

 

11. Han Y, Shao Y, Lin Z, Quyang L, Wang H, Zhou Y,Chen W, Chen Y, Chen WL, Hu FR, Li W, Liu Z.Netrin-1 SimultaneouslySuppresses Corneal Inflammation and Neovascularization.Invest Ophthalmol VisSci. 2012 , 53(3):1285-95.

 

12. Chen W, Li Z, Hu J, Zhang Z, Chen L, ChenY, Liu Z. Corneal alternations induced by topical application ofbenzalkonium chloride in rabbit. PLoS One. 2011;6(10):e26103.

 

13. Sun X, Wang X, Chen T, Li T, Cao K, LuA, Chen Y, Sun D, Luo J, Fan J, Young W, Ren Y. Myelin activatesFAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response inmurine system.PLoS One. 2010;Feb 23;5(2):e9380.

 

14、To YF, Sun RW, Chen Y, Chan VS, Yu WY, Tam PK, Che CM, Lin CL.Gold(III) porphyrin complex is more potent than cisplatin in inhibiting growthof nasopharyngeal carcinoma in vitro and in vivo.Int J Cancer. 2009;124(8): 1971-9.

 

15. Xie Y, Chan H, Fan J, Chen Y, Young J, LiW, Miao X, Yuan Z, Wang H, Tam PK,  Ren Y.  Involvement ofvisinin-like protein-1 (VSNL-1) in regulating proliferative and invasiveproperties of neuroblastoma.Carcinogenesis. 2007;28(10):2122-30.

 

16. Chen Y, Chan VS, Zheng B, Chan KY, Xu X,To LY, Huang F, Khoo US, Lin CL. A novel subset of putativestem/progenitor CD34+Oct4+ cells is the major target for SARS coronavirus inhuman lung. The Journal of Experimental Medicine. 2007; 204(11):2529-2536.

 

17. Chan VS#, Chan KY#, Chen Y#, Poon LL,Cheung AN, Zheng B, Chan KH, Mak W, Ngan HY, Xu X, Screaton G, Tam PK, AustynJM, Chan LC, Yip SP, Peiris M, Khoo US, Lin CL. Homozygous L-SIGN (CLEC4M)plays a protective role in SARS coronavirus infection. Nat Genet.2006; 38(1):38-46.

 

18. Fan J,  Chen Y, Chan HM, Tam PK, Ren Y.Removing intensity effects and identifying significant genes for Affymetrixarrays in macrophage migration inhibitory factor-suppressed neuroblastomacells. Proc Natl Acad Sci USA. 2005; 102(49):17751-6.

 

19. Ren Y, Chan H, Fan J, Xie Y, Chen Y, Li W,Jiang G, Liu Q, Meinhardt A, Tam PK. Inhibition of growth and metastasis invitro and in vivo by targeting marophage migration inhibitory factor in humanneuroblastoma. Oncogene. 2006; 25(25):3501-8.

 

20. Ren Y,  Cao B, Law S, Xie Y, Lee PY,Cheung L, Chen Y, Huang X, Chan HM, Zhao P, Luk J, Vande Woude G, Wong J.Hepatocyte growth factor promotes cancer cell migration and angiogenic factorsexpression: a prognostic marker of human esophageal squamous cell carcinomas.Clin Cancer Res. 2005;11(17):6190-7.

 

21. Ren Y,  Lin CL, Li Z, Chen Y, HuangX, Lui V, Nicholls J, Lan Hy, Tam PK. Up-regulation of macrophage migrationinhibitory factor in infants with acute neonatal necrotizing enterocolitis.Histopathology. 2005;46(6):659-67.

 

22.  Zhang HY,  Nanji AA, Luk JM, huangXR, Lo CM, Chen YX, Yuen ST, Lan HY, Lau GK. Macrophage migrationinhibitory factor expression correlates with inflammatory changes in humanchronic hepatitis B infection. Liver Int. 2005;25(3):571-9.

 

23. Ren Y, Tsui HT, Poon RT, Ng IO, Li Z, ChenY, Jiang G, Lau C, Yu WC, Bacher M, Fan ST. Macrophage migration inhibitoryfactor: roles in regulating tumor cell migration and expression ofangiogenic factors in hepatocellular carcinoma. Int J Cancer. 2003;107(1):22-9.

 

24. Yu CM,  Lai KW, Chen YX, Huang XR,Lan HY. Expression of macrophage migration inhibitory factor in acute ischemicmyocardial injury. J Histochem Cytochem. 2003;51(5):625-31.

 

25. Xiong HQ, Chen YX, Yi YJ, Tsuchiya K,Moeckel G, Cheung J, Liang D, Tham K, Xu XH, Chen XZ, Pei Y, Zhao ZJ, Wu GQ. Anovel gene encoding a TIG multiple domain protein is a positional candidate forautosomal recessive polycystic kidney disease. Genomics2002; 80(1):96-104.

 

主持课题:

1.     国家自然科学基金,血管紧张素II阳性新型肺干细胞来源和分化的研究,2011.01-2013.12

2.     国家自然科学基金,血管紧张素转化酶II阳性干细胞分化成角膜树突状细胞的类型和功能的研究,2014.01-2017.12

3.     国家自然科学基金,角膜基质细胞重塑细胞外基质引导角膜新生血管形成的机制研究,2016.01-2019.12


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